Research Topics

  1. Home /
  2. Research Topics /
  3. Also used in ECMO! Elucidating the Mechanism of Functional Expression of Antithrombogenic Polymers
header image

Also used in ECMO! Elucidating the Mechanism of Functional Expression of Antithrombogenic Polymers

Cover Image for Also used in ECMO! Elucidating the Mechanism of Functional Expression of Antithrombogenic Polymers

Also used in ECMO! Elucidating the Mechanism of Functional Expression of Antithrombogenic Polymers

Successful analysis of water molecules as scaffolds for the barrier layer of blood components

We have succeeded in elucidating the mechanism by which the antithrombotic properties of poly(2-methoxyethyl acrylate) (PMEA), which is actually used in the inner wall coating of ECMO circuits, develop.

The University has also issued a press release.

Abstract

Interactions involving intermediate water are crucial for the design of novel blood-compatible materials. Herein, we use a combination of atomic force microscopy, quartz crystal microbalance measurements, and soft X-ray emission spectroscopy to investigate the local hydrogen-bonded configuration of water on blood-compatible poly(2-methoxyethyl acrylate) and non-blood-compatible poly(n-butyl acrylate) grafted on a gold substrate. We find that the initially incorporated water induces polymer-dependent phase separation, facilitating further water uptake. For the blood-compatible polymer, tetrahedrally coordinated water coexists with water adsorbed on C═O groups in low-density regions of the grafted polymer surface, providing a scaffold for the formation of intermediate water. The amount of intermediate water is determined by the type of functional groups, local polymer configuration, and polymer morphology. Thus, blood compatibility is governed by the complex water/polymer interactions.


Paper Information

Title:
Hydration mechanism in blood-compatible polymers undergoing phase separation
Author:
Daiki Murakami, Kosuke Yamazoe, Shin-nosuke Nishimura, Naoya Kurahashi, Tomoya Ueda, Jun Miyawaki, Yuka Ikemoto, Masaru Tanaka, and Yoshihisa Harada
Journal name:
Langmuir
DOI:
10.1021/acs.langmuir.1c02672