In the near-future cancer medical system that Society 5.0 aims for, non-invasive diagnostic and treatment technologies that emphasize quality of life (QOL) are required. To achieve this, it is necessary to obtain big data for analyzing the relationship between biochemical reactions in cancer cells and clinical cases. Therefore, the development of innovative materials for this purpose is highly desired. Today, attention is being paid to the visualization of the biological response of cancer cells using acoustic waves such as shock waves and ultrasound, which are mechanical actions, and the development of new materials to attack (treat) cancer cells. In our laboratory, we are developing innovative pressure-sensitive supramolecular soft materials (organic, supramolecular, and polymeric) that can measure the actual pressure (acoustic waves) applied to cells.