Our research group designs and synthesizes useful bioactive organic molecules based on synthetic organic chemistry, and develops novel and effective synthetic methods. Recent studies: 1. synthesis of apoptosis inhibitors, antitumor agents, and plant growth regulators; 2. new synthetic methods using ynolates; 3. synthesis of functional iptycenes; 4. molecular release reactions; 5. elucidation of the cancer-induced immunosuppression; 6. generation of anticancer reagents based on the novel mechanistic insights.